TriMix Definition: TriMix is a common term used to describe a mixture of Papaverine, Phentolamine, and Alprostadil (PGE). These drugs produce a vasodilating effect when injected into the penis, relaxing and dilating the blood vessels. The American Urological Society recognizes TriMix injection therapy as a viable treatment for erectile dysfunction.

The TriMix injection is administered using a very small needle inserted into the proper area along the shaft of the penis, so the drug mixture is delivered into the corpus cavernosum. The mix of drugs causes the corpus cavernosum to relax, dilate, and become filled with blood, producing an erection.

TriMix is generally an effective, low-cost treatment for ED, especially for those patients who have not had good results or experience moderate to severe side effects from PDE5 inhibitors (Viagra®, Levitra®, Cialis®).

TriMix injections offer a solution for ED that is:

  • Safe
  • Reliable
  • Fast-acting
  • Long-lasting
  • More affordable than oral medications
  • Not affected by alcohol consumption

According to the American Urologic Association, an intracavernous injection is the most effective non-surgical treatment for ED. Penile injections, unlike most oral medications, can trigger an automatic erection in less than 5 minutes. In addition, triMix medication can provide longer and fuller erections that may last through the climax, allowing you to maintain and improve your sexual health.

What Is Erectile Dysfunction?

So, what is erectile dysfunction, exactly? Erectile dysfunction is sexual dysfunction characterized by the inability to develop or maintain an erection sufficient for intercourse. While erectile dysfunction can affect men of any age, it is most common in men over the age of 40. Studies have estimated that the number of men with erectile dysfunction in the United States is more than 30 million. Learn more about erectile dysfunction and penile injection medications today.

Symptoms and Causes

The inability to achieve or maintain an erection can affect a man at any time. It can happen once in a while or more frequently, and there can be many different causes. Some common causes include:

  • Low testosterone
  • Cardiovascular disease
  • Diabetes
  • Prostate issues
  • Depression
  • Anxiety
  • Nerve/spinal cord damage
  • Effects of taking medication

Treatment Options

Pharmacies compound various forms of popular oral medications for erectile dysfunction, such as:

  • Sildenafil (compare to Viagra): Available in capsules or rapid dissolve tablets (dissolve under the tongue)
  • Vardenafil (compare to Levitra): Available in capsules or rapid dissolve tablets (dissolve under the tongue)
  • Tadalafil (compare to Cialis): Available in capsules or rapid dissolve tablets (dissolve under the tongue)

Our clinic also offers more than 40 combinations of TriMix, a popular penile injection therapy medication. Our TriMix medications are backed by a full stability study and cGMP testing of every batch.

Goals of TriMix Injection Treatment

Our TriMix injection treatment plans aim to provide men with a reliable, easy-to-use, safe method of achieving and maintaining an erection suitable for sexual relations. There are many benefits to using TriMix injections for ED: they’re safe, effective, easy to store, long-lasting, easy to administer and more. Once you receive a prescription, or if you have additional questions, contact us.

Alternative to Tablets

TriMix injections are an alternative to PDE5 Inhibitor tablets (Viagra®, Levitra®, Cialis®) and are most commonly comprised of a mixture of three drugs; phentolamine, papaverine and alprostadil. These penile injections can be especially useful when patients are unable to take PDE5 Inhibitors because they are taking nitrates, certain beta-blockers, or if they experience severe side effects from the oral medications.

7 Things to Know About TriMix Injections:

1. Trimix injections are safe

All of our formulas undergo extensive third-party testing before being released to patients. TriMix injections are a common and well-tolerated method of obtaining an erection used by men with symptoms of ED for more than 30 years. It’s especially useful for men with severe ED caused by high blood pressure, high cholesterol, smoking, diabetes and obesity.

2. Trimix injections are effective

TriMix ED injections are incredibly effective. According to the American Urologic Association, intracavernous injections like TriMix are currently the most effective option for non-surgical ED treatment.

3. Trimix injections act quickly

Unlike oral ED medications, TriMix injections trigger an automatic erection — most in 10 minutes or less. Some men may not begin to see the effect until after sexual foreplay has begun. In the beginning, we recommend using a lower dose to prevent prolonged erections. A doctor may recommend adjusting your dosage after the initial exposure.

4. Trimix injections are long-lasting

TriMix injections provide longer and fuller erections than most oral alternatives that can last through the climax, helping men achieve improved sexual health and performance. Erections should last between one and two hours.

When using TriMix or any other ED medication, an erection should never last four or more hours. Erections that last more than four hours are considered a medical emergency. Please immediately contact your local emergency room to be treated if you are experiencing this symptom.

5. Trimix injections are easy to self-administer

For some, penile injections may seem too painful to self-administer. However, for many who’ve tried TriMix, the process couldn’t be easier and more painless! Check out these simple self-injection instructions to see how easy it can be to do it yourself:

  • Wash your hands with soap and water and keep the penis clean.
  • Keep the TriMix cold and the syringe sterilized.
  • Administer the injection at the 9-11 and 1-3 o’clock positions, between the base and mid-portion of the penis.
  • Dispose of your needle properly after injection.

6. Trimix injections aren’t affected by alcohol consumption

Unlike some medications, the effectiveness of TriMix injections is not usually altered by consuming alcohol. While using this medication, patients can drink responsibly and still have the same results as they would have without it.

7. Trimix injections are easy to store

TriMix injections are best stored in the refrigerator (between 32 – 39°F) and should be kept away from light. If your prescription is for more than one vial of medication, please store your medication as follows:

  • Store the TriMix vial being actively used at normal refrigeration temperature. For convenience, TriMix can be stored at room temperature for short periods while in use. However, every effort should be made to keep the medication refrigerated or frozen. When traveling, TriMix can be transported with an ice pack.
  • The remaining TriMix vials should be placed in a freezer and kept frozen. Frozen vials (between 0-31°F) have a beyond-use date of up to one year.

TriMix is shipped with ice packs. It is normal for the ice packs to melt and the medication to arrive unfrozen or even slightly warm. The effectiveness of the medication is not compromised. TriMix is shipped overnight to ensure stability and optimum results.

TriMix Injection Dosage

The initial Trimix Injection dose should be .05cc to .2cc, depending on the patient’s level of ED. Wait 48 hours before increasing dosage. Then, increase by 0.025 cc to 0.050 cc until a satisfactory dose is reached. The maximum dose is 0.50 cc. Do not be discouraged by a poor result with the first few injections, as the initial dose should be kept low to avoid a prolonged erection.

Trimix Injection Instructions

Inside the brown bottle, you’ll find the antidote to the medication, which is called Phenylephrine. Inside the clear bottle, you’ll find the TriMix medication.

To get started, you’ll want to remove the syringe from the packaging. There’s a protective cap over the needle on the syringe, and there’s also a protective cap on the back of the syringe. You’ll use the alcohol prep pad to clean the top of the vial as well as the injection site.

On the top of the TriMix vial, there’s a protective seal. You’ll want to remove the protective seal and expose the rubber membrane.

Open the alcohol prep pad and use it to clean the rubber membrane on the top of the TriMix vial. Remove the cap on the back of the syringe, exposing the plunger.

Then, remove the front cap and expose the needle. Before you place the syringe inside the vial, you’ll want to draw back the same amount of units you’ve been prescribed to inject. In this case, we’re going to draw up 20 units into the syringe.

Insert the syringe into the vial through the rubber membrane. You’ll want to press down on the plunger and push the air into the vial. You’ll then want to slowly draw back the required amount of units into the syringe. Pull the syringe straight out of the vial, set the vial down, and then re-cap the front of the syringe.

The area of the penis that you’re injecting the medication into is called the corpus cavernosum. The corpus cavernosum runs on either side of the penis. You’ll want to make sure to inject at the 10 o’clock or 2 o’clock position.

Do not inject on the same side each time you use the medication. You’ll want to make sure that you’re alternating sides between usage. This diagram shows where the corpus cavernosum is located inside the penis.

Before you apply the medication, you’ll want to clean the area of injection with the alcohol prep pad. As you go to apply the medication, make sure that you don’t pull on the penis or twist the penis in any way, because this may affect the injection site.

Now, you’re ready to apply the medication. You’ll want to remove the cap, and in one swift motion, you’ll apply the medication. Make sure that you avoid any veins. Pull the syringe straight out of the penis.

After injecting, you’ll want to apply pressure to the injection site. You’ll then want to massage the area of entry for about one minute and allow the medication to spread evenly throughout the entire penis.

To give you an idea of the amount of pressure you’ll want to apply to the plunger when you go to administer the medication, try drawing up water into one of the syringes. You’ll place your thumb on the back of the plunger and lightly press on the back of the plunger.

This is the same amount of pressure you’ll want to apply to the plunger when you go to inject the TriMix medication. If you find that you have to apply more pressure than this, then you may not be in the corpus cavernosum, which means the medication will not be effective.

If you experience an erection lasting longer than two hours, you’ll want to apply the antidote to the medication, which is called Phenylephrine.

You’ll apply the Phenylephrine the same way you apply the TriMix medication. First, draw up air into the syringe, and then insert the syringe into the vial of Phenylephrine. Slowly draw back 50 units of Phenylephrine into the syringe. Pull the syringe straight out of the vial and then re-cap the front of the syringe.

You’ll want to inject one inch above the base of the penis at the 10 o’clock or 2 o’clock position. You want to make sure that you avoid any veins. And again, you’ll want to massage the area of entry for about one minute right after you administer the medication.

To ask any additional questions, be sure to get in touch with our team of experts.